منابع مشابه
Modularity of stress response evolution.
Responses to extracellular stress directly confer survival fitness by means of complex regulatory networks. Despite their complexity, the networks must be evolvable because of changing ecological and environmental pressures. Although the regulatory networks underlying stress responses are characterized extensively, their mechanism of evolution remains poorly understood. Here, we examine the evo...
متن کاملEvolution of Characters and Modularity
In a review of biological usage of the word "character", Colless [4] classi es three di erent types of usage. The rst kind, which he calls an attribute, denotes "a distinctive attribute, quality, or property of structure, form, material, or function". The second kind, which he calls feature, denotes "a part, often of a more or less physical nature, but generally . . .more abstract". The nal kin...
متن کاملAdaptive Evolution of a Stress Response Protein
BACKGROUND Some cancers are mediated by an interplay between tissue damage, pathogens and localised innate immune responses, but the mechanisms that underlie these linkages are only beginning to be unravelled. METHODS AND PRINCIPAL FINDINGS Here we identify a strong signature of adaptive evolution on the DNA sequence of the mammalian stress response gene SEP53, a member of the epidermal diffe...
متن کاملSpontaneous evolution of modularity and network motifs.
Biological networks have an inherent simplicity: they are modular with a design that can be separated into units that perform almost independently. Furthermore, they show reuse of recurring patterns termed network motifs. Little is known about the evolutionary origin of these properties. Current models of biological evolution typically produce networks that are highly nonmodular and lack unders...
متن کاملThe evolution of modularity in genome architecture
It has been suggested that the capacity to evolve can itself evolve. One factor that may be important in determining evolvability is modularity of the genotype-phenotype map. A related phenomenon is modularity in genome architecture, in which genes with epistatic effects are colocalized on the chromosome. This changes a population’s response to recombination by maximizing recombination among ge...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0709764105